Using a module exchange approach, we have tested a longstanding model for the role of Cro repressor in λ prophage induction. This epigenetic switch from lysogeny to the lytic state occurs on ...
During development, many crucial genes help organisms form properly. One of those genes is myogenic determination gene number 1 (MyoD), which can exert a powerful influence as a “genome organizer." It ...
Crystal structures of the Lac repressor, with and without isopropylthiogalactoside (IPTG), and the repressor bound to operator have provided a model for how the binding of the inducer reduces the ...
A high throughput screen of >30,000 diverse repressor domains from across the tree of life identifies repressor domains with unique structures that underpin enhanced epigenetic effector domain potency ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, No. 24 (Dec. 15, 1986), pp. 9353-9357 (5 pages) ...
For large-scale industrial production of high-value therapeutic proteins, mammalian cell lines form a vital platform. Unfortunately, this production is often hampered by low predictability and ...
An international team of researchers has unraveled a new regulatory mechanism how food components and environmental factors influence the immune system. Various substances present in the intestines ...
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